HighQC™ Human Bone Marrow Stromal Cells (Postnatal)
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On request
quantity
Produktdetaljer
Katalognummer: 870 - ABC-TC3518
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 1 vial
Parameters
| Storage and shipping | Liquid Nitrogen |
|---|
ABC-TC3518
HighQC™ Human Bone Marrow Stromal Cells (Postnatal)
Human bone marrow stromal cells or mesenchymal stem cells (MSCs) are derived from bone marrow mononuclear cells. MSCs are isolated from a single donor. MSCs are one of the most investigated cells for therapeutic applications. These cells enable researchers to investigate stem cell properties, regenerative medicine, and tissue engineering. In addition, they may be used for developmental studies. Development period: Postnatal
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ABC-TC3519
HighQC™ Human Bone Marrow Stromal Cells (Prenata)
Human bone marrow stromal cells or mesenchymal stem cells (MSCs) are derived from bone marrow mononuclear cells. MSCs are isolated from a single donor. MSCs are one of the most investigated cells for therapeutic applications. These cells enable researchers to investigate stem cell properties, regenerative medicine, and tissue engineering. In addition, they may be used for developmental studies.Development period: Prenata
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ABC-SC0095T
HighQC™ Human Bone Marrow CD34+ Stem/Progenitor Cells
CD34+ stem cells are multipotent and can give rise to all cell types in blood. CD34 cells are most known for its expression on hematopoietic progenitor cells found in bone marrow and cord blood. While compromising only 1.5% of bone marrow mononuclear cell population, CD34 stem cells are responsible for all lymphohematopoietic lineages and are now commonly used clinically as they have been shown to provide long-term durable donor-derived host lymphohematopoietic reconstitution.CD34+ cells are isolated using positive immunomagnetic cell separation procedures from bone marrow.
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ABC-TC3337
HighQC™ Chorionic Mesenchymal Cells
Human Chorionic Mesenchymal Stem Cells (hCMesenchymal Stem Cells) are derived from extraembryonic mesoderm and are isolated from fresh chorion following mechanical and enzymatic removal of the trophoblastic layer. They adhere and proliferate well in cell culture and retain their stem cell characteristics beyond passage 10. Differentiation of hCMesenchymal Stem Cells to all three germ layers, ectoderm (neural), mesoderm (skeletal muscle, cardiomyocytic and endothelial) and endoderm (pancreatic) has been reported. The embryonic stemcell marker SSEA-4 has been identified on hCMesenchymal Stem Cells as well as CD349 and CD140b.
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ABC-TC002T
HighQC™ Mouse Regulatory T Cells
We have a large selection of cryopreserved murine immune system spleen cells, bone marrow cells, dendritic cells, and peritoneal macrophages. Immunophenotyping is included in the Certificates of Analysis.
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ABC-SC0114T
HighQC™ Human IPSC-Derived Cardiac Cells: I-HCm
Human iPSC-Derived Cardiac Cells contain i-HCm make a powerful in vitro platform to study cardiac physiology and disease, and to assess therapeutic compound efficacy, safety and toxicity1-3. These iPSC-Derived Cardiac Cells are differentiated from integration-free Human Induced Pluripotent Stem Cells (HiPSC), which are fully validated for pluripotency and cultured under feeder-free conditions before cryopreservation. Through a robust serum-free, chemically defined protocol, high yields of fully functional Cardiac Cells are obtained and cryopreserved. Of note, the i-HCm and other cardiac cell populations are not purified through genetic selection, and thus there is no risk of genotoxic stress due to molecular manipulation. Furthermore, cellular preparations include accessory cellular populations resident in the human heart, which are crucial for correct cardiomyocyte physiology2, 4.CharacterizationPost-thawing viability and plating efficiencies of the cells are typically higher than 50%. After plating at the recommended density, the cells will show spontaneous synchronized beating, and will express typical cardiomyocyte markers, such as the contractile proteins cardiac troponin T (cTNT) and sarcomeric alpha actinin (SaAct). The cardiomyocyte content of our preparations is determined by flow cytometry analysis and quantification of cardiac troponin T positive cells. These iPSC-Derived Cardiac Cells are also tested to ensure the absence of microorganism contaminants.ApplicationsIndependent assays: From electrophysiology and multi-electrode array analysis to high content microscopy and viability screens.Cardiac Disease modeling: To date, interesting phenotypes of several genetic-based cardiomyopathies have been successfully replicated in a dish through the use of patient-specific i-HCm. Examples include Familial Hypertrophic, Dilated, and Arrhythmogenic Right Ventricular Cardiomyopathies1-3.Cardiac safety and toxicity: Cardiac toxicity is an important contributor for the failure of therapeutic agents in late stages of clinical trials, as well as for the removal of approved drugs from the market. Through the CiPA initiative, which brings together researchers from institutions such as the FDA, academic institutions and pharmaceutical companies, i-HCm are being evaluated as an integral tool for the safety assessment of developing drugs5,6.
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