HighQC™ Human IPSC-Derived Neural Stem Cell-Epilepsy Patient
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On request
quantity
Produktdetaljer
Katalognummer: 870 - ABC-SC0065T
Produktkategori: Företag och industri > Vetenskap och laboratorium
Gentaur
Storlek: 1 vial
Parameters
| Storage and shipping | Liquid Nitrogen |
|---|
ABC-SC0065T
HighQC™ Human IPSC-Derived Neural Stem Cell-Epilepsy Patient
Gentaur Human iPSC-Derived Neural Stem Cells (NSCs) are derived from integration-free, induced pluripotent stem cells (iPSCs) under fully defined neural induction conditions. The NSCs express typical markers of cerebral cortical neural stem and progenitor cells such as PAX6, FOXG1 and nestin, and spontaneously form polarized neural tube-like rosette structures when plated as a monolayer in culture (see below). Additionally, Gentaur NSCs are capable of generating a spectrum of cerebral cortical excitatory and inhibitory neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. After thawing and plating, the neural stem cells terminally differentiate to acquire mature electrophysiological properties, and form functional synaptic networks over a period of 40 ~ 50 days. Gentaur NSCs are easy to differentiate to neurons or mixed neural cell types, following our protocols and using our tailored media and reagent bundles. A highly pure population of neurons can be generated from Gentaur NSCs following the synchronous differentiation protocol. Using our specialized coating reagents, neurons derived from Gentaur NSCs can be maintained in culture long-term (andgt;1 year). NSCs are available from multiple donors to suit your research needs and have been characterized extensively.
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ABC-SC0066T
HighQC™ Human IPSC-Derived Neural Stem Cell-Trisomy X Patient
Trisomy X (Triple X) syndrome occurs at a frequency of approximately 1 in 1000 newborn females. The syndrome is associated with an increased risk of seizures and may affect short-term memory and learning although the majority of women affected show few clinical symptoms. Gentaur has developed iPSC-derived neural stem cells from a patient with the triple X chromosomal abnormality. All of the iPS cells examined (20 individual cells karyotyped), had trisomy X.Gentaur Human iPSC-Derived Neural Stem Cells (NSCs) are derived from integration-free, induced pluripotent stem cells (iPSCs) under fully defined neural induction conditions. The NSCs express typical markers of cerebral cortical neural stem and progenitor cells such as PAX6, FOXG1 and nestin, and spontaneously form polarized neural tube-like rosette structures when plated as a monolayer in culture (see below). Additionally, Gentaur NSCs are capable of generating a spectrum of cerebral cortical excitatory and inhibitory neurons that are electrically active and have the ability to form functional synapses and circuits in vitro. After thawing and plating, the neural stem cells terminally differentiate to acquire mature electrophysiological properties, and form functional synaptic networks over a period of 40 ~ 50 days.Gentaur NSCs are easy to differentiate to neurons or mixed neural cell types, following our protocols and using our tailored media and reagent bundles. A highly pure population of neurons can be generated from Gentaur NSCs following the synchronous differentiation protocol. Using our specialized coating reagents, neurons derived from Gentaur NSCs can be maintained in culture long-term (andgt;1 year). NSCs are available from multiple donors to suit your research needs and have been characterized extensively.
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ABC-SC0075T
HighQC™ Human IPSC-Derived Neural Stem Cell
Human Neural Stem Cells from Gentaur are differentiated from a human induced pluripotent stem cell line (hiPSC), which is generated using mRNA reprogramming technology from Human Dermal Fibroblasts (HDF). The monolayer HDF-hiPSC are efficiently converted to neural epithelium using HPSC Neural Induction Medium, a serum-free medium for rapid and efficient neural induction of human pluripotent stem cells (hPSCs). Synergistic inhibition of glycogen synthase kinase 3 (GSK3) and transforming growth factor b (TGF-b) differentiates HDF-hiPSCs to homogenous neural stem cells (NSC) in the presence of human leukemia inhibitory factor (LIF) within 7 days.The derived NSC are characterized by immunofluorescence with antibodies specific to nestin and SOX2. The cell population is highly pure: andgt;90% of cells express Nestin and andgt;80% of cells are SOX2 positive. After reviving, NSC can be maintained in HPSC Neural Induction Medium as an adherent culture or form neural spheres in EGF and bFGF containing neural stem cell medium. The cells are able to form rosette and neural tube-like structures after being passaged and plated at high density on Matrigel coated culture vessels in neural stem medium containing EGF and bFGF. HiPSC-NSC can be further expanded for months as a monolayer on MatrigelTM coated culture vessels or in suspension as neural spheres when seeded on ultra-low binding culture vessels in neural stem cell medium. NSC are multipotent and able to differentiate into various neuronal and glial subtypes. Specific patterning cues, such as SHH, retinoic acid and FGF8, can be added after reviving to direct the cells to different neural lineages.HiPSC-NSC are cryopreserved at passage 0 and delivered frozen. Each vial contains andgt;1 x 10^6 cells in 1 ml volume. Cells are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi.
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ABC-SC2100
HighQC™ Human IPSC-Derived Endothelial Colony Forming Cells
Human iPSC-Derived Endothelial Colony Forming Cells from a healthy female donor. The cells resemble primary human endothelial colony forming cells with high proliferative and angiogenic potential. The endothelial colony forming cells can achieve up to 19 population doublings
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ABC-SC0130T
HighQC™ Adipose Derived Adult Stem Cell (POOLED)
As interest grows in the expanding field of stem cell research, areas such as regenerative medicine, tissue engineering and basic stem cell biology necessitate a reliable cost-effective cell-based tool for use in discovery and design projects. Adipose-derived adult stem cells and their unique differentiation properties can be utilized in any number of research applications and offer decided benefits over similar multipotent cell types.Adipose tissue is typically in greater supply enabling ample sourcing for isolation and production of adult stem cells – at a fraction of the cost for bone marrow-derived counterparts while maintaining similar markers and characteristics. Adult stem cells offer another more subtle benefit allowing scientists to circumvent the ethical issues normally associated with employing embryonic stem cells in biomedical research.Gentaur adult stem cells are available with optimized media formulations to maximize growth, survival and differentiation in culture. All cells have been screened negative for HIV-1, HIV-2, HTLC-1, HTLV-2, Hep-B, Hep-C, and mycoplama.
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ABC-SC0116T
HighQC™ Mouse Neural Stem Cell: MNSC (Brain Cerebral Cortex)
Mouse Neural Stem Cells (MNSC) are multipotent, and can be induced to differentiate into neurons, astrocytes and oligodendrocytes that make up the central nervous system (CNS). Neurospheres transplanted into intact brain can survive, expand and differentiate into mature neurons, astrocytes and oligodendrocytes in 3 weeks. The ability of neural stem cells to retain multi-lineage potential and proliferate extensively in vitro provides new avenues for the treatment of neural degenerative diseases and injuries.Isolated from fetal or adult mouse brains, MNSC are maintained in an undifferentiated, proliferative state by culturing them as free floating neurospheres in serum-free medium optimized with growth factors. MNSC are cryopreserved at first passage and can be cultured and propagated for 1-2 passages prior to induction of phenotypic differentiation. Differentiated MNSCs are positive for β-tubulin III, GFAP and the oligodendrocyte marker O4 when cultured in Mouse Neural Differentiation Medium. The cells form neurospheres in Mat Neural Stem Cell Growth Medium.
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